Effects of ziprasidone, SCH23390 and SB277011 on spatial memory in the Morris water maze test in naive and MK-801 treated mice

Tanyeri,Tanyeri P., Buyukokuroglu M. E., Mutlu O., Ulak G., Akar F., Celikyurt I. K., ...Daha Fazla

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.138, ss.142-147, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 138
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.pbb.2015.09.014
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.142-147
  • Anahtar Kelimeler: Ziprasidone, SCH23390, SB277011, Cognition, Morris water maze, MK-801, Mice, COGNITIVE IMPAIRMENT, RECEPTOR ANTAGONIST, CHRONIC NICOTINE, NMDA RECEPTOR, SCHIZOPHRENIA, RATS, DIZOCILPINE, GLUTAMATE, PERFORMANCE, DEFICITS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Introduction: Patients with schizophrenia have cognitive dysfunctions: positive psychotic symptoms are the primary purposes for schizophrenia treatment Improvements in cognitive function should be a characteristic of all newly developed drugs for the treatment of schizophrenia with dementia. Thus, we investigated the effects of the second-generation antipsychotic ziprasidone, dopamine D1 antagonist SCH-23390 and dopamine D3 antagonist SB-277011 on spatial learning and memory.