Effects of ziprasidone, SCH23390 and SB277011 on spatial memory in the Morris water maze test in naive and MK-801 treated mice

Tanyeri,Tanyeri P., Buyukokuroglu M. E., Mutlu O., Ulak G., Akar F., Celikyurt I. K., ...More

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol.138, pp.142-147, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138
  • Publication Date: 2015
  • Doi Number: 10.1016/j.pbb.2015.09.014
  • Journal Name: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.142-147
  • Keywords: Ziprasidone, SCH23390, SB277011, Cognition, Morris water maze, MK-801, Mice, COGNITIVE IMPAIRMENT, RECEPTOR ANTAGONIST, CHRONIC NICOTINE, NMDA RECEPTOR, SCHIZOPHRENIA, RATS, DIZOCILPINE, GLUTAMATE, PERFORMANCE, DEFICITS
  • Kocaeli University Affiliated: Yes

Abstract

Introduction: Patients with schizophrenia have cognitive dysfunctions: positive psychotic symptoms are the primary purposes for schizophrenia treatment Improvements in cognitive function should be a characteristic of all newly developed drugs for the treatment of schizophrenia with dementia. Thus, we investigated the effects of the second-generation antipsychotic ziprasidone, dopamine D1 antagonist SCH-23390 and dopamine D3 antagonist SB-277011 on spatial learning and memory.