Effects of ziprasidone, SCH23390 and SB277011 on spatial memory in the Morris water maze test in naive and MK-801 treated mice


Tanyeri,Tanyeri P., Buyukokuroglu M. E. , Mutlu O. , Ulak G. , Akar F. , Celikyurt I. K. , ...More

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol.138, pp.142-147, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138
  • Publication Date: 2015
  • Doi Number: 10.1016/j.pbb.2015.09.014
  • Title of Journal : PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Page Numbers: pp.142-147

Abstract

Introduction: Patients with schizophrenia have cognitive dysfunctions: positive psychotic symptoms are the primary purposes for schizophrenia treatment Improvements in cognitive function should be a characteristic of all newly developed drugs for the treatment of schizophrenia with dementia. Thus, we investigated the effects of the second-generation antipsychotic ziprasidone, dopamine D1 antagonist SCH-23390 and dopamine D3 antagonist SB-277011 on spatial learning and memory.