The effect of combined preinduction thoracic epidural anaesthesia and glucocorticoid administration on perioperative interleukin-10 levels and hyperglycemia. A randomized controlled trial

Kilickan L., YUMUK Z., Bayindir O.

JOURNAL OF CARDIOVASCULAR SURGERY, cilt.49, sa.1, ss.87-93, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 1
  • Basım Tarihi: 2008
  • Dergi Adı: JOURNAL OF CARDIOVASCULAR SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.87-93
  • Anahtar Kelimeler: anesthesia, epidural, anaesthesia, general, blood glucose, interleukin-10, cardiac surgical procedures, CARDIOPULMONARY BYPASS, CARDIAC-SURGERY, INFLAMMATORY RESPONSE, METABOLIC RESPONSE, OXYGEN ANESTHESIA, HEART-SURGERY, GLUCOSE, STRESS, METHYLPREDNISOLONE, MORTALITY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Aim. Anti-inflammatory cytokines such as interleukin-10 (IL-10) play a key role in the anti-inflammatory cascade after cardiopulmonary bypass (CPB). Even moderate hyperglycemia. can increase mortality/morbidity, stroke, and myocardial infarction after coronary artery bypass grafting (CABG). The purpose of our study was to investigate whether preinduction thoracic epidural anesthesia (TEA) and preinduction glucocorticoid have an effect on perioperative anti-inflainmatory and perioperative hyperglycemia in patients undergoing CABG with CPB.