The effect of combined preinduction thoracic epidural anaesthesia and glucocorticoid administration on perioperative interleukin-10 levels and hyperglycemia. A randomized controlled trial

Kilickan L., YUMUK Z., Bayindir O.

JOURNAL OF CARDIOVASCULAR SURGERY, vol.49, no.1, pp.87-93, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 1
  • Publication Date: 2008
  • Journal Name: JOURNAL OF CARDIOVASCULAR SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.87-93
  • Keywords: anesthesia, epidural, anaesthesia, general, blood glucose, interleukin-10, cardiac surgical procedures, CARDIOPULMONARY BYPASS, CARDIAC-SURGERY, INFLAMMATORY RESPONSE, METABOLIC RESPONSE, OXYGEN ANESTHESIA, HEART-SURGERY, GLUCOSE, STRESS, METHYLPREDNISOLONE, MORTALITY
  • Kocaeli University Affiliated: Yes

Abstract

Aim. Anti-inflammatory cytokines such as interleukin-10 (IL-10) play a key role in the anti-inflammatory cascade after cardiopulmonary bypass (CPB). Even moderate hyperglycemia. can increase mortality/morbidity, stroke, and myocardial infarction after coronary artery bypass grafting (CABG). The purpose of our study was to investigate whether preinduction thoracic epidural anesthesia (TEA) and preinduction glucocorticoid have an effect on perioperative anti-inflainmatory and perioperative hyperglycemia in patients undergoing CABG with CPB.