Akademik Veri Yönetim Sistemi
International Journal of Medical Biochemistry, cilt.8, sa.4, ss.292-299, 2025 (Scopus, TRDizin)
Objectives: The aim was to investigate the effects of cinnamon on the kidney tissue serum endoplasmic reticulum
(ER) stress marker, reticulone (RTN)1A, receptor for advanced glycation end products (RAGE) and the lipid peroxidation
indicator, malondialdehyde (MDA) in an experimental diabetes mellitus (DM) rat model.
Methods: Twenty-eight male Wistar Albino rats (six months old and weighing 350–400 g) were divided equally into
four groups: 1) Control group - citrate buffer (0.2 M, pH 4.4; ip); 2) Cinnamon group - cinnamon (600 mg/kg/day, orogastric
tube); 3) DM group -STZ (35 mg/kg, ip); and 4) DM + cinnamon group; Cinnamon and STZ were given at the same
doses and route as in Groups 2 and 3, respectively. At the end of the 12-week experiment period, serum, urine and kidney
tissue samples were taken from all groups. Serum RTN 1A, RAGE, MDA, urea, blood urea nitrogen (BUN), creatinine
levels andkidney tissue RTN 1A, RAGE and MDA levels were measured.
Results: Our biochemical results showed that there was a statistically significant decrease in RAGE and MDA levels
in the DM + cinnamon group compared to the DM group (p<0.05). In addition, the decrease in serum urea, BUN, and
creatinine levels in the DM + cinnamon group was also remarkable (p<0.05). Althought histologically no widespread
necrosis was observed, cortical interstitial vascular dilatation was observed in DM+cinnamon group.
Conclusion: Cinnamon was effective in reducing markers of oxidative stress and ER stress including RAGE and MDA, in kidney tissue in an animal model of diabetic nephropathy.
Keywords: Cinnamon, diabetic nephropathy, endoplasmic reticulum stress, malondialdehyde, receptor for advanced
glycation end products, reticulon 1A
Berrin Oztas1, Fatma Ceyla Eraldemir1, Sezgi Akbal2, Esra Acar3, Fatih Hunc1,
Melda Yardimoglu Yilmaz2
1Department of Medical Biochemistry, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye
2Department of Histology and Embryology, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye
3Department of Biochemistry, Kocaeli Health and Technology University Faculty of Pharmacy, Kocaeli, Türkiye
Abstract
How to cite this article: Oztas B, Eraldemir FC, Akbal S, Acar E, Hunc F, Yardimoglu Yilmaz M. Can cinnamon reduce endoplasmic reticulum stress in diabetic nephropathy?: An experimental rat model. Int J Med Biochem 2025;8(4):292–299.