A Comprehensive Review of Transcranial Direct Current Stimulation (tDCS): Mechanisms, Cognitive Effects, Applications, and Future Directions


SALEH R. A. A., Nasser S. F., Almakhathy A. F., Al-Koshab M. M.

5th International Conference on Emerging Smart Technologies and Applications, eSmarTA 2025, Ibb, Yemen, 5 - 06 Ağustos 2025, (Tam Metin Bildiri) identifier identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1109/esmarta66764.2025.11132143
  • Basıldığı Şehir: Ibb
  • Basıldığı Ülke: Yemen
  • Anahtar Kelimeler: Brain stimulation, EEG system, Review, Transcranial direct current stimulation (tDCS)
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Transcranial direct current stimulation (tDCS) has emerged as a prominent, non-invasive brain stimulation technique with applications spanning cognitive enhancement and neurorehabilitation. This review synthesizes current evidence regarding tDCS mechanisms, from cellular-level effects to network-level reorganization, and evaluates its efficacy across cognitive and clinical domains. We examine fundamental principles, including polarity-dependent modulation of cortical excitability, protocol optimization, and safety considerations. Applications in working memory, executive function, language rehabilitation, and neuropsychiatric disorders are critically analyzed, highlighting both promising results and limitations. Emerging directions, including high-definition tDCS, personalized dosing, and multimodal interventions, are discussed. The review concludes with recommendations for standardizing protocols and addressing current challenges in reproducibility and individual variability.