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Asian Journal of Cell Biology, vol.10, no.2, pp.25-34, 2015 (Scopus)
Multiple Sclerosis (MS) is a chronic demyelinating disease of the Central Nervous System (CNS) that manifests with inflammation and axonal degeneration. We decided to perform a meta-analysis to pool all available results of the association between IL-10 (!1082G/A) polymorphism and MS risk. This is a genetic meta-analysis conducted with respect to the association between the IL-10 polymorphism and MS risk. We accomplished a search in PubMed and Scopus databases to identify articles published up to Jun 2013 that examined the associations between IL-10 (1082 G/A) polymorphism and MS. Odds Ratios (OR) with the 95% Confidence Intervals (CI) were used to assess the association. A total of eight case-control studies, including 1517 cases and 1059 controls were selected. All the proposed models were associated with a non-significant increased risk of MS. The A allele carriers (homo and heterozygotes) had a 50% non-significant increased risk of MS, when compared with the homozygote G (OR = 1.50, 95% CI = 0.91-2.48, p = 0.111). In the subgroup analysis by ethnicity, non-significant increased MS risks were found among Europeans for all genetic models and the A allele carriers (homo and heterozygotes) had a 59% non-significant increased risk of MS (OR = 1.59, 95% CI = 0.91-2.79, p = 0.104). For Asian ethnicity (Iran), also no significant association between this polymorphism and MS risk was observed in all comparison models. This meta-analysis provided evidence that IL-10 (!1082 G/A) polymorphism is associated with an increased risk of MS, especially in Europeans. Current knowledge is not sufficient to explain the role of the aforementioned polymorphisms in MS pathogenesis.