Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: Role of endothelium and duration of bile duct ligation

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Utkan N. Z., Utkan T., Sarıoğlu Y., Gönüllü N. N.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.27, ss.339-344, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1046/j.1440-1681.2000.03256.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.339-344
  • Anahtar Kelimeler: dog, 5-hydroxytryptamine, nitric oxide, noradrenaline, obstructive jaundice, vascular smooth muscle, VASCULAR SMOOTH-MUSCLE, NITRIC-OXIDE, RELAXING FACTOR, RATS, REACTIVITY, HYPOTENSION, CHOLESTASIS, CIRCULATION, KIDNEY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

1. We examined the effects of experimental obstructive jaundice caused by bile duct ligation (BDL) on vascular smooth muscle function, as well as the underlying mechanisms involved, by recording responses to noradrenaline (NA), 5-hydroxy-tryptaminc (5-HT) and acetylcholine (ACh) in canine isolated renal arteries and to NA in Isolated mesenteric arteries in vitro. All studies were performed 7 days after the onset of BDL in renal arteries and 3, 7 and 15 days after the onset of BDL in mesenteric arteries.