Post-sigh breathing behavior and spontaneous pauses in the C57BL/6J (B6) mouse

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Yamauchi M., Ocak H., Dostal J., Jacono F. J., Loparo K. A., Strohl K. P.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, cilt.162, sa.2, ss.117-125, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 162 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.resp.2008.05.003
  • Dergi Adı: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.117-125
  • Anahtar Kelimeler: apnea, sighs, periodic breathing, respiratory control, SPONTANEOUS CENTRAL APNEAS, SUDDEN-INFANT-DEATH, VENTILATORY BEHAVIOR, HEALTHY INFANTS, SLEEP-APNEA, HEART-RATE, VARIABILITY, INSTABILITY, STRAIN, A/J
  • Kocaeli Üniversitesi Adresli: Evet

Özet

The purpose was to examine sighs and spontaneous pauses in regard to the stability of resting breathing in the B6 strain, compared to the A/J strain. A 5-HT1A receptor agonist (buspirone) and a chromosomal substitution strain (Mal) were used to further alter breathing patterning. Ten-minute recordings of room air breathing were collected from unanaesthetized B6, A/J, and B6a1 mice. Despite no differences between strains in the magnitude and incidence of sighs, post-sigh apneas, the variation for duration of expiration (T-e) after sighs, and the number of spontaneous pauses were greater in the B6, while Shannon Entropy (nonlinear metrics) for T-e after sighs was lower in B6, compared to the other strains. Buspirone and chromosomal substitution eliminated post-sigh apneas and decreased spontaneous pauses. A greater irregularity and the lower complexity of post-sigh breathing in B6 are reversed by elements on A/J chromosome 1 and by increased 5-HT1A serotonergic tone. (C) 2008 Elsevier B.V. All rights reserved.