Akademik Veri Yönetim Sistemi
Diğer, ss.23-24, 2022
Introduction:This study examines the changes in tumor characteristics and progression in patients with early-stage breast cancer from diagnosis until surgery through a protein-restricted diet and physical exercise. Materials-Methods: Eighty patients diagnosed with breast cancer in our clinic and clinically stage I-II were divided into two groups. Patients in the study group were given an isocaloric protein-restricted (7%) diet and 10,000-step walking exercise every three days under the guidance of a dietitian. The patients in the control group were also given an isocaloric 21% protein diet. Blood was drawn from the patients on the morning of the first day of diet and the morning of the surgery day. Serum markers such as IGF-1, TNFα, FGF, VEGF, insulin, and sex hormones were checked from blood samples. In addition, the patients' tumor diameters and histopathological Ki67 ratios were compared before and after diet. Results:The results were compared separately within the ER (+), PR (+), HER2 (-), Luminal A, and Luminal B HER2 (-) subgroups. It was observed that the tumor diameters of the patients in the control group increased, and Ki67 ratios increased until the day of surgery, while there was no significant increase in tumor size and Ki67 ratio in the study group. In addition, a significant decrease was detected in the IGF-1, TNFα, and VEGF levels of the patients in the study group. Conclusion: The prolongation of the process from the time of diagnosis to the day of surgery in patients with breast cancer may adversely affect the prognosis of the tumor. In cases such as the Covid 19 pandemic, preoperative herpes labialis infection, and upper respiratory tract infection, where this process may be prolonged, it may be possible to reduce or stop tumor progression by making protein-restricted diet and physical activity. Keywords: breast cancer, protein-restricted diet, Ki67, IGF-1, VEGF