Response to interferon-alpha in chronic hepatitis B patients with and without precore mutant strain and effects on HBsAg Titers


Akhan S. C. , Yulugkural Z., Vahaboglu H.

CHEMOTHERAPY, vol.53, pp.402-406, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1159/000109770
  • Title of Journal : CHEMOTHERAPY
  • Page Numbers: pp.402-406

Abstract

Background: Chronic hepatitis B ( CHB) affects 400 million people worldwide and is a major cause of morbidity and mortality. It is known that HBV DNA sequences were detected after the clearance of serum hepatitis B surface antigen ( HBsAg) often in serum, liver and peripheral blood mononuclear cells. The objectives of our study were to evaluate the previous measurements of HBsAg titers versus. quantitative hepatitis B virus ( HBV) DNA and ALT measurements in order to predict the nonresponse and response in interfer-on-alpha (IFN-alpha)- treated HBeAg- positive and HBeAg- negative chronic HBV patients. Methods: We investigate whether the presence of precore mutant affects the response to IFN-alpha therapy and on the titer of HBsAg or not. Twenty-one HBeAg- positive ( group1), 38 HBeAg- negative ( group 2), and 47 healthy inactive carriers ( group 3) made up this study. Liver biopsy showed chronic hepatitis, there was no cirrhosis and none of the patients had IFN-alpha therapy before. Results: The decrease in HBsAg titers was found as statistically not significant in groups 1 ( p = 0.192) and 3 ( p = 0.236) and statistically significant in group 2 ( p = 0.0001) within a 6- month interval. Conclusion: HBsAg titer may be a factor to predict the primary responders and nonresponders specially in HBeAg- negative patients.