Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury


Ekici M. A. , Uysal O., Cikriklar H. I. , Ozbek Z., Cosan D. T. , Baydemir C. , ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.18, no.1, pp.10-27, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2014
  • Title of Journal : EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Page Numbers: pp.10-27

Abstract

OBJECTIVE: Studies in animals have provided key evidence that antagonizing TNF-alpha is a viable therapeutic strategy for diffuse severe brain injury. This study is planned to prevent post-traumatic secondary tissue damages in rat diffuse severe brain injury model, which is induced by alone or combined administration of Etanercept and lithium chloride (LiCl).