A case of acetaminophen (paracetamol) causing renal failure without liver damage in a child and review of literature

Ozkaya O., Genc G., Bek K., Sullu Y.

RENAL FAILURE, vol.32, no.9, pp.1125-1127, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 32 Issue: 9
  • Publication Date: 2010
  • Doi Number: 10.3109/0886022x.2010.509830
  • Journal Name: RENAL FAILURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1125-1127
  • Keywords: children, acetaminophen, renal failure, pathophysiology, nephrotoxicity
  • Kocaeli University Affiliated: No

Abstract

Acetaminophen (paracetamol) is a widely used drug and known as a safety antipyretic and analgesic drug in childhood. Acetaminophen-associated liver damage is more recognized than kidney damage. Nephrotoxicity and hepatotoxicity can be seen together after acetaminophen overdose, but renal damage without liver damage is a rarely seen entity in all age groups being reported more rarely in childhood. We present here a 16-year-old girl with renal failure without liver damage because of acetaminophen toxicity and a review of literature for pathophysiological mechanisms, clinical course, treatment, and outcome.