Akademik Veri Yönetim Sistemi
IV. Türkiye in vitro Diyagnostik (IVD) Sempozyumu, İzmir, Türkiye, 20 - 22 Şubat 2019, cilt.44, sa.1, ss.40, (Özet Bildiri)
OP-6
RETROSPECTIVE EVALUATION OF THE RELATIONSHIP
BETWEEN CTX AND 25 OH D3 LEVELS BY LABORATORY
DATABASE AS BONE RESORPTION MARKER
Fatih Hunç, Şule Koç, Ezginur Kocakır, Fatma Ceyla Eraldemir, Hale
Maral Kır
Kocaeli University, Faculty of Medicine, Medical Biochemistry, Kocaeli,
Turkey
Objectives: 5 OH D3 is important for bone health especially in the
elderly population. C-terminal telopeptide of type 1 collagen (CTX) is a
resorption biomarker for bone turnover. In this study, we evaluated
CTX and 25 OH D3 levels together.
Materials-Methods: The data of this study were obtained
retrospectively from the Central Laboratory Database of Kocaeli
University Faculty of Medicine Education and Research Hospital. Total
number of 110 patients with simultaneous 25 OH D3 and C-terminal
telopeptide (CTX) serum levels were included in the study. Statistical
analysis was performed with IBM SPSS 20. 0 (SPSS Inc. , Chicago, IL,
USA) package program. The difference between the groups was
determined by Mann Whitney U Test for the numerical variables, that
were not normally distributed. The relationship between continuous
variables was performed by Spearman correlation analysis. P<0. 05
was considered sufficient for statistical significance.
Results: tatistical analysis findings of this study: CTX and 25 OH D3
measurements were not normally distributed. There were no
statistically significant differences between genders in terms of age. In
women, 25 OH D3 levels were higher than men, while CTX levels were
lower. However, no statistically significant difference was found for these
variables. The relationship between 25 OH D3 and CTX was
found to be moderately negative in males in the Spearman's rho
correlation analysis, whereas in women it was weaker in the same
direction. Age of 50 was considered as the critical threshold for
menopause. For a standard analysis with the women, men were
similarly divided into women under the age of 50 and above. In men
under 50 years of age, 25 OH D3 levels were significantly lower than
men over 50 years of age. The same state for CTX is valid. There
wasn't found statistically difference between women under 50 years of
age and over 50 years of age in terms of both D3 and CTX.
Conclusions: We found that, especially in men comparison to women,
high 25 OH D3 levels may be associated with decreased bone
resorption.
Keywords: 25-OH D3, CTX, gender, bone turnover