Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.34, sa.4, ss.353-362, 2014 (Scopus)
Objective: To investigate the volumetric changes in hippocampal and extrahippocampal regions by using magnetic resonance volumetry (MRV), and to explore the relation between these volumetric changes and etiological and clinical factors among patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Material and Methods: The study group consisted of 64 subjects [28 patients (14 right, 14 left MTLE-HS) and 36 healthy controls]. Hippocampus, amygdala, parahippocampal gyrus (PHG), thalamus, cerebellum and corpus callosum (CC) volumes were compared among and within three groups. Volumetric measurements were investigated according to the comparison of etiological and clinical factors in the patient group. Results: Bilateral hippocampus, amygdala, parahippocampal gyrus and thalamus volumes were significantly different whereas corpus callosum and cerebellar volumes were not significantly different among three groups. In the comparison of volumetric changes within each group, ipsilateral hippocampal, amygdala, parahippocampal gyrus and thalamus volumes were smaller in right and left MTLE-HS patients compared to the controls. In patients with history of febrile convulsions (FC), left hippocampus and bilateral thalamic volumes were found significantly smaller than the patients without history of FC. A negative correlation was found between seizure frequency and left hippocampus, left amygdale and left cerebellum volumes whereas duration of epilepsy was negatively correlated with left PHG and left thalamic volumes. Conclusion: Atrophic changes are not only limited to the hippocampus but also can expand to parahippocampal and extrahippocampal regions in patients with MTLE-HS. History of FC, increased seizure frequency, and duration of epilepsy may be related factors with these changes.