Akademik Veri Yönetim Sistemi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, cilt.306, 2025 (SCI-Expanded, Scopus)
Advancing hydrogel technology with tunable mechanical strength and sustained release is critical for therapeutic applications in drug delivery and tissue engineering. Conventional single polymer networks, including semiinterpenetrating polymer network (SIPN) hydrogels, often lack mechanical robustness and controlled release needed for therapeutic use. In this study, we fabricated a biocompatible interpenetrating polymer network (IPN) hydrogel with improved properties for controlled protein release. We employed a facile one-pot synthesis approach that integrated aqueous Diels-Alder (DA) 'click' chemistry with photopolymerization methods to crosslink gelatin methacryloyl (GelMA) within a polymeric framework of poly(ethylene) glycol bismaleimide (PEGMI) and multi-furan-modified polyethylene glycol (PEGFU). Spectroscopy (FTIR and 1H NMR) confirmed the chemical composition of the hydrogels. The effect of varying polymer ratios on hydrogel properties was assessed to optimize protein release and mechanical behavior. Fully crosslinked IPN hydrogels exhibited enhanced energy dissipation and compressive moduli 2.5- to 3.5-fold relative to SIPN hydrogels across various polymer ratios. Release kinetics followed the Korsmeyer-Peppas mathematical model, indicating sustained release. IPN hydrogels demonstrated good water absorption, moderate degradation, and favorable biocompatibility with 3T3 fibroblast cells. Overall, these findings highlight the potential of IPN hydrogels as a promising drug delivery platform for advancing regenerative therapies and targeted treatment strategies.