Objective: In this study, we aimed to evaluate how university students can cope with stress and their general health questionnaire scores using regression. Material and Methods: The survey including socio-demographic characteristics, the ways of coping with stress inventory, and the general health questionnaire was applied to 6386 students who volunteered to participate. All participants were enrolled in university in Eskisehir during the 2004-2005 academic years. Results: The mean score of students in the general health survey was 1.93 +/- 0.03 (mean standard error of mean). According to the General Health Questionnaire-12 (GHQ-12), 3800 (59.5%) students were healthy, 1282 (20.1%) had probable psychological disorder and 1304 (20.4%) had physiological and psychological disorders. The mean scores of students in the subscales of coping with the stress inventory were 2.07 +/- 0.01 for self-confident approach, 1.77 +/- 0.01 for optimistic approach, 1.17 +/- 0.01 for unconfident self approach, 0.89 +/- 0.01 for submissive approach and 1.90 +/- 0.01 for social support seeking approach. There was a negative correlation between the GHQ-12 score and self confident approach (r = -0.28, p < 0.001), optimistic approach (r = -0.25, p < 0.001) and social support seeking approach (r = 0.14, p < 0.001). Similarly, there was a considerable positive correlation between submissive approach (r = 0.17, p < 0.001) and unconfident self approach (r = 0.39, p < 0.001). Conclusion: University students seem to require psychological support and lose their ability to cope with problems effectively when their GHQ-12 scores are higher.