Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature

MEHTAP Ö., Atesoglu E. B., GONULLU E., KESKİ H., Hacihanefioglu A.

TURKISH JOURNAL OF HEMATOLOGY, vol.28, no.2, pp.142-145, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 28 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.5152/tjh.2011.32
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.142-145
  • Kocaeli University Affiliated: Yes

Abstract

Cup-like morphology is defined as cup-like nuclear invagination spanning >= 25% of the nuclear diameter in >10% of blasts. Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia (AML) patients. Herein we describe a patient with cup-like blasts that was diagnosed and treated for common acute lymphoblastic leukemia (ALL). In contrast to the literature, the presented case was Philadelphia chromosome positive and FLT3 ITD negative. (Turk J Hematol 2011; 28: 142-5)