Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature

MEHTAP Ö., Atesoglu E. B., GONULLU E., KESKİ H., Hacihanefioglu A.

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, sa.2, ss.142-145, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.32
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.142-145
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Cup-like morphology is defined as cup-like nuclear invagination spanning >= 25% of the nuclear diameter in >10% of blasts. Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia (AML) patients. Herein we describe a patient with cup-like blasts that was diagnosed and treated for common acute lymphoblastic leukemia (ALL). In contrast to the literature, the presented case was Philadelphia chromosome positive and FLT3 ITD negative. (Turk J Hematol 2011; 28: 142-5)