Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature

MEHTAP Ö. , Atesoglu E. B. , GONULLU E., KESKİ H., Hacihanefioglu A.

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, ss.142-145, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 28 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.32
  • Sayfa Sayıları: ss.142-145


Cup-like morphology is defined as cup-like nuclear invagination spanning >= 25% of the nuclear diameter in >10% of blasts. Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia (AML) patients. Herein we describe a patient with cup-like blasts that was diagnosed and treated for common acute lymphoblastic leukemia (ALL). In contrast to the literature, the presented case was Philadelphia chromosome positive and FLT3 ITD negative. (Turk J Hematol 2011; 28: 142-5)