Synthesis and carbonic anhydrase inhibitory properties of tetrazole- and oxadiazole substituted 1,4-dihydropyrimidinone compounds

Celik F., Arslan M., KAYA M. O., Yavuz E., Gencer N., Arslan O.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.42, sa.1, ss.58-62, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/21691401.2013.769448
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.58-62
  • Anahtar Kelimeler: carbonic anhydrase, dihydropyrimidinone, enzyme, inhibitor, oxadiazole, tetrazole, THERAPEUTIC APPLICATIONS, MEDICINAL CHEMISTRY, ISOFORMS I, DIHYDROPYRIMIDINONES, ERYTHROCYTE, COUMARINS, ACID, PURIFICATION, DERIVATIVES, ACTIVATORS
  • Kocaeli Üniversitesi Adresli: Evet

Özet

A new series of tetrazole-, oxadiazole-and cyanosubstituted 1,4-dihydropyrimidinone compounds were synthesized, and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I were evaluated. 4-Cyanophenyl-1,4- dihydropyrimidinone compounds were prepared with 1,3-diketone, cyanobenzaldehyde and urea. The compounds were reacted with sodium azide and then with anhydride to get the final products. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. The compound 4-(1,7,7-trimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazoline- 4-yl) benzonitrile 6c (IC50 = 0.0547 mM) has the most inhibitory effect.