Akademik Veri Yönetim Sistemi
MEDICAL JOURNAL OF BAKIRKOY, cilt.20, sa.4, ss.296-301, 2024 (ESCI)
Objective: Somatotroph adenomas account for approximately 5%-15% of pediatric pituitary adenomas and are more common in males. The aim of this study was to discuss the early and late outcomes of endoscopic pediatric growth hormone (GH)-secreting pituitary adenoma surgery performed at a high-volume tertiary hospital. Methods: A total of 4875 consecutive patients underwent endoscopic transsphenoidal surgery between August 1997 and December 2022 in Kocaeli University Medical Faculty Neurosurgery Department and Pituitary Research Center. We reviewed the medical data, radiological images, and surgical videos of these patients and included 19 (0.39%) pediatric patients aged 18 years with pathologically identified GH-secreting pituitary Results: The data of 19 pediatric patients with GH-secreting pituitary adenoma were pathologically identified at our institution and retrospectively analyzed. 8 (42.1%) participants were male and 11 (57.9%) were female. Gross total resection (GTR) was performed in 10 (52.6%) patients, and subtotal resection was performed in 9 (47.4%) patients. 9 (47.4%) patients met the criteria for remission. Statistically significant results for adenoma size on GTR were obtained (p-value: 0.021). Sphenoid sinus pneumatization was not associated with resection rate (p-value 0.264). The absence of cavernous sinus invasion was significant as a positive predictive value for GTR, but it was not significant for remission (p-value:0.027-0.102, respectively). Conclusion: Somatotroph adenomas in pediatric patients are rare and challenging lesions. Adenoma size and cavernous sinus invasion are effective for resection. Sphenoid sinus pneumatization does not affect the resection rate in experienced centers.