Effects of Olanzapine and Clozapine on Depression and Anxiety in Mice: Alterations in Brain Neurotrophic Factor Expression Levels

Gumuslu, Esen; Mutlu, OĞUZ

doi:10.5152/jarem.2019.2209

Effects of Olanzapine and Clozapine on Depression and Anxiety in Mice: Alterations in Brain Neurotrophic Factor Expression Levels

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Gumuslu E., Mutlu O.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, vol.9, pp.97-101, 2019 (ESCI)

Publication Type: Article / Article
Volume: 9
Publication Date: 2019
Doi Number: 10.5152/jarem.2019.2209
Journal Name: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Page Numbers: pp.97-101
Kocaeli University Affiliated: Yes

Abstract

Objective: Schizophrenia, is an important brain neurodevelopmental disorder observed in 1% of the global population. Classical antipsychotics cause extrapyramidal side effects and are less effective on the negative symptoms of schizophrenia. New-generation atypical antipsychotics have been developed as alternatives to typical antipsychotics for more effective on negative symptoms of schizophrenia such as mood and memory disorders or safer therapy. Olanzapine and clozapine are new atypical antipsychotics that are frequently used in clinics.