Effects of Olanzapine and Clozapine on Depression and Anxiety in Mice: Alterations in Brain Neurotrophic Factor Expression Levels

Gumuslu E., Mutlu O.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, vol.9, pp.97-101, 2019 (ESCI) identifier


Objective: Schizophrenia, is an important brain neurodevelopmental disorder observed in 1% of the global population. Classical antipsychotics cause extrapyramidal side effects and are less effective on the negative symptoms of schizophrenia. New-generation atypical antipsychotics have been developed as alternatives to typical antipsychotics for more effective on negative symptoms of schizophrenia such as mood and memory disorders or safer therapy. Olanzapine and clozapine are new atypical antipsychotics that are frequently used in clinics.