Effects of Olanzapine and Clozapine on Depression and Anxiety in Mice: Alterations in Brain Neurotrophic Factor Expression Levels

Gumuslu, Esen; Mutlu, OĞUZ

doi:10.5152/jarem.2019.2209

Effects of Olanzapine and Clozapine on Depression and Anxiety in Mice: Alterations in Brain Neurotrophic Factor Expression Levels

Atıf İçin Kopyala

Gumuslu E., Mutlu O.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, cilt.9, ss.97-101, 2019 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9
Basım Tarihi: 2019
Doi Numarası: 10.5152/jarem.2019.2209
Dergi Adı: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.97-101
Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Schizophrenia, is an important brain neurodevelopmental disorder observed in 1% of the global population. Classical antipsychotics cause extrapyramidal side effects and are less effective on the negative symptoms of schizophrenia. New-generation atypical antipsychotics have been developed as alternatives to typical antipsychotics for more effective on negative symptoms of schizophrenia such as mood and memory disorders or safer therapy. Olanzapine and clozapine are new atypical antipsychotics that are frequently used in clinics.