This study aims at exploring the effect of models, a contemporary method, in teaching and learning of meiosis division. Mixed method was used in this research. The data about their level achievement were collected through an achivement test developed by the researchers and also their opinions about this study were collected interviewing technique. The research was conducted with 47 samples that were 2nd. grade students of science and technology teaching department at "Biology Laboratory-I" course. Control group was examined slides under the microscope and taught by lecture method. Experimental group was taught by using models in addition to examining slides under the microscope and was also asked to produce their model. The results showed that teaching meiosis division using models is significantly more effective on students success in post test.