Biofilm Formation on Phosphorylcholine-Modified 3D-Printed Dental Resin
2026 Continental European Division (Lisbon, Portugal), Lisbon, Portekiz, 3 - 05 Eylül 2026, ss.0-1, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Lisbon
- Basıldığı Ülke: Portekiz
- Sayfa Sayıları: ss.0-1
- Kocaeli Üniversitesi Adresli: Evet
Özet
Objectives: The aim of this study was to evaluate the effect of 2-methacryloyloxyethyl phosphorylcholine (MPC), a zwitterionic monomer with protein-repellent and anti-biofilm properties, on biofilm formation in 3D-printed dental resin compared with enamel.
Methods: Enamel specimens prepared from extracted human teeth were used as a control group. Disc-shaped resin specimens (10 mm in diameter and 2 mm in thickness) were fabricated using a 3D printer and divided into three groups: unmodified dental resin (0 wt% MPC), 1 wt% MPC, and 2 wt% MPC (n = 15 per group). A salivary pellicle was formed using artificial saliva to simulate oral conditions, and specimens were incubated with Streptococcus mutans, Streptococcus sanguinis, and Candida albicans for 48 h to allow biofilm formation. Biofilm formation was evaluated using an MTT assay. Data were analyzed using one-way ANOVA and Tukey post hoc tests.
Results: Biofilm formation differed significantly among the tested materials (F(3, 56) = 35.186, p < 0.001). The highest biofilm formation was observed on enamel, followed by the unmodified resin group. Both 1 wt% and 2 wt% MPC-modified resin groups showed significantly lower biofilm formation than the unmodified resin group (p < 0.001). There was no significant difference between the 1 wt% and 2 wt% MPC groups (p > 0.05).
Conclusions: Incorporation of MPC into 3D-printed dental resin significantly reduced biofilm formation, indicating that zwitterionic modification may be a promising approach for reducing biofilm formation on 3D-printed dental materials.