Involvement of serotonin receptor subtypes in the antidepressant-like effect of trim in the rat forced swimming test

Ulak G., Mutlu O., Tanyeri P., Komsuoglu F. İ., Akar F., Erden B. F.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.95, sa.3, ss.308-314, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.pbb.2010.02.006
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.308-314
  • Anahtar Kelimeler: Antidepressant-like effect, Forced swimming test, TRIM, 5-HT receptor, NITRIC-OXIDE SYNTHASE, NOS INHIBITOR 1-(2-TRIFLUOROMETHYLPHENYL)-IMIDAZOLE, IMIDAZOLE TRIM, DOPAMINE RELEASE, 5-HT1B RECEPTORS, ANIMAL-MODEL, IN-VITRO, ANTAGONISTS, DEPRESSION, MEDIATION
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Depression is a common illness with severe morbidity and mortality. Nitric oxide synthase (NOS) inhibitors are shown to elicit antidepressant-like effect in various animals models. It is widely known that serotonin plays an important role in the antidepressant-like effect of drugs. The aim of this study is to investigate the involvement of 5-HT1 and 5-HT2 receptor subtypes in the antidepressant-like effect of TRIM, a nNOS inhibitor, in the rat forced swimming test (FST). TRIM displays an antidepressant-like activity in FST which is blocked by pretreatment with the NOS substrate L-arginine. Depletion of endogenous serotonin using para-chlorophenylalanine (pCPA: 3 x 150 mg/kg, i.p.) partially attenuated TRIM (50 mg/kg)-induced reductions in immobility time in FST. Pretreatment with methiothepin (0.1 mg/kg, i.p, a non-selective 5-HT receptor antagonist), cyproheptadine (3 mg/kg i.p, a 5-HT2 receptor antagonist) or ketanserin (5 mg/kg i.p, a 5HT(2A/2c) receptor antagonist) prevented the effect of TRIM (50 mg/kg) in the FST. WAY 100635 (0.1 mg/kg i.p, a selective 5-HT, A receptor antagonist) and GR 127935 (3 mg/kg i.p, a selective 5-HT1B/1D receptor antagonist) slightly reversed the immobility-reducing effect of TRIM in the FST, but this failed to reach a statistically significant level. The results of this study demonstrate that antidepressant-like effect of TRIM in the FST seems to be mediated, at least in part, by an interaction with 5-HT2 receptors while non-significant effects were obtained with 5-HT1 receptors. (C) 2010 Elsevier Inc. All rights reserved.