Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease

Akboga M. K., Balci K. G., Maden O., Ertem A. G., Kirbas O., Yayla C., ...More

BIOMARKERS IN MEDICINE, vol.10, no.4, pp.375-383, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.2217/bmm-2015-0050
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.375-383
  • Keywords: high SYNTAX score, inflammation/oxidative stress, monocyte/HDL-cholesterol ratio, DENSITY-LIPOPROTEIN CHOLESTEROL, ACUTE CATHETERIZATION, INTERVENTION, SEVERITY, ATHEROSCLEROSIS, INFLAMMATION, ASSOCIATION, MORTALITY, BIOLOGY, EVENTS
  • Kocaeli University Affiliated: Yes

Abstract

Aim: We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. Patients & methods: In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were classified into two groups, low SYNTAX score (<= 22) and high SYNTAX score (>= 23). Results: MHRs were significantly higher in patients with high SYNTAX score (p < 0.05). In multivariate regression analysis, MHR remained as independent predictor of high SYNTAX score together with C-reactive protein (CRP), hypertension and diabetes mellitus. In correlation analysis, MHR showed significant positive correlations with SYNTAX score (r = 0.371, p < 0.001) and CRP level (r = 0.336, p < 0.001). Conclusion: This study suggests MHR is independently associated with burden of coronary atherosclerosis.