Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease

Akboga M. K. , Balci K. G. , Maden O., Ertem A. G. , Kirbas O., Yayla C., ...Daha Fazla

BIOMARKERS IN MEDICINE, cilt.10, ss.375-383, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 10 Konu: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2217/bmm-2015-0050
  • Dergi Adı: BIOMARKERS IN MEDICINE
  • Sayfa Sayıları: ss.375-383

Özet

Aim: We aimed to investigate whether baseline monocyte to high-density lipoprotein cholesterol ratio (MHR), an easily available inflammatory and oxidative stress marker, is associated with SYNTAX score. Patients & methods: In this cross-sectional study, n = 1229 consecutive patients with coronary artery disease were classified into two groups, low SYNTAX score (<= 22) and high SYNTAX score (>= 23). Results: MHRs were significantly higher in patients with high SYNTAX score (p < 0.05). In multivariate regression analysis, MHR remained as independent predictor of high SYNTAX score together with C-reactive protein (CRP), hypertension and diabetes mellitus. In correlation analysis, MHR showed significant positive correlations with SYNTAX score (r = 0.371, p < 0.001) and CRP level (r = 0.336, p < 0.001). Conclusion: This study suggests MHR is independently associated with burden of coronary atherosclerosis.