High expression of CD8 in the tumor microenvironment is associated with PD-1 expression and patient survival in high-grade serous ovarian cancer

Creative Commons License

Olmez F., Oglak S. C., Olmez O. F., Akbayir O., Yilmaz E., Akgol S., ...More

TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol.19, no.3, pp.246-256, 2022 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.4274/tjod.galenos.2022.59558
  • Journal Name: TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.246-256
  • Keywords: High-grade serous ovarian cancer, programmed death-1 receptor, tumor-infiltrating lymphocytes, INFILTRATING T-CELLS, PROGNOSTIC-SIGNIFICANCE, NEOADJUVANT CHEMOTHERAPY, FAVORABLE PROGNOSIS, LYMPHOCYTES, DEATH-1, CD103
  • Kocaeli University Affiliated: Yes

Abstract

Objective: The current study assesss programmed death-1 (PD-1) receptor expression and CD3, CD4, and CD8 tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSOC) and to associate our results with neoadjuvant chemotherapy history and disease prognosis.