Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers


Guven O. O. , Erdogan T. , Goker H., Yildiz S.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.17, no.8, pp.2233-2236, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1016/j.bmcl.2007.01.061
  • Title of Journal : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Page Numbers: pp.2233-2236

Abstract

In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 mu g/mL against S. aureus and MRSA, respectively. (c) 2007 Elsevier Ltd. All rights reserved.