Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.17, sa.8, ss.2233-2236, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 8
- Basım Tarihi: 2007
- Doi Numarası: 10.1016/j.bmcl.2007.01.061
- Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2233-2236
- Anahtar Kelimeler: phenyl, 1H-benzimidazole, benzyl ether, antibacterial, antifungal, ANTIFUNGAL ACTIVITY, DERIVATIVES
- Kocaeli Üniversitesi Adresli: Hayır
Özet
In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 mu g/mL against S. aureus and MRSA, respectively. (c) 2007 Elsevier Ltd. All rights reserved.