Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers


Guven O. O. , Erdogan T. , Goker H., Yildiz S.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.17, ss.2233-2236, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 17 Konu: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.bmcl.2007.01.061
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Sayfa Sayısı: ss.2233-2236

Özet

In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 mu g/mL against S. aureus and MRSA, respectively. (c) 2007 Elsevier Ltd. All rights reserved.