Synthesis and antifungal activity of new dihydrofurocoumarins and dihydrofuroquinolines


USTALAR A., YILMAZ M. , OSMANİ A., KEÇELİ S. A.

TURKISH JOURNAL OF CHEMISTRY, vol.41, no.1, pp.80-88, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.3906/kim-1604-22
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.80-88

Abstract

We investigated the radical addition of 4-hydroxycoumarin (la) and 4-hydroxyquinoline (lb) with conjugated dienes (2a-f) mediated by cerium(IV) ammonium nitrate (CAN) resulting in ethenyl substituted 2,3-dihydrofurocoumarin (3a-f) and 3,5-dihydrofuroquinoline (3g, 3h) compounds in moderate to good yields. All compounds were characterized by spectroscopic methods (IR, MS, and H-1 and C-13 NMR) and microanalysis. Antifungal activities of these compounds were investigated against the fungi Candida albicans, C. parapsilosis, C. krusei, C. glabrata, C. tropicalis, and Aspergillus fumigatus.