Akademik Veri Yönetim Sistemi
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, cilt.31, sa.3, ss.205-211, 2024 (Hakemli Dergi)
Objective
Primary hyperparathyroidism (PHPT) is a common
endocrine disease that is characterized by
hypercalcemia and commonly associated with
parathyroid adenoma (PTA). Hypocalcemia is a
common postoperative complication in patients with
PHPT. The neutrophil-to-lymphocyte ratio (NLR) and
platelet-to-lymphocyte ratio (PLR) are inexpensive
hematological inflammatory markers. We aimed to
investigate the potential predictive risk factors, including
the hemogram-derived inflammatory markers for early
postoperative hypocalcemia in patients with PHPT.
Material and Method
Patients diagnosed with PHPT, underwent
parathyroidectomy and histopathologically shown to
be caused by a single PTA were included.
Results
NLR was significantly correlated with parathormone
(PTH), while PLR was related considerably with only
NLR. A significant positive correlation was shown
between gland weight, volume, calcium (Ca), and
PTH levels. A significant correlation of postoperative
hypocalcemia with age, preoperative Ca, PTH, and
NLR was also demonstrated.
Conclusion
We found that NLR was significantly higher in
patients with PHPT who developed postoperative
hypocalcemia; however, our regression analysis did
not find elevated NLR as a significant predictive risk
factor for postoperative hypocalcemia. To the best
of our knowledge, this is the first study investigating
the relationship between hemogram-derived
inflammatory markers and clinical parameters, such
as the development of postoperative hypocalcemia
and preoperative nephrolithiasis, in patients with
PHPT.