Locotomor Activity, Learning and Memory in WAG/Rij Rats with Absence Epilepsy

KARSON A. , Onat F., Balci F., ATEŞ N.

EPILEPSI, vol.14, no.3, pp.167-175, 2008 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 2008
  • Title of Journal : EPILEPSI
  • Page Numbers: pp.167-175


Objectives: The aim of this study was to evaluate the behavioral characteristics of WAG/Rij rats, a genetic model for absence epilepsy. Materials and methods: The performance of WAG/Rij rats in passive avoidance, Morris-water maze and open-field tests were compared with the Wistar rats (control group). Results: Passive avoidance and rota-rod performance did not differ between the two groups. WAG/Rij rats exhibited longer escape latencies on the first day of training in Morris water-maze, however, this difference disappeared with further training and during the probe day (without the platform). WAG/Rij rats exhibited increased locomotor activity in the open-field test. Discussion: Results are discussed with respect to known behavioral and cognitive deficits that characterize patients with absence epilepsy.