Netrin-1 in cancer: Potential biomarker and therapeutic target?
TUMOR BIOLOGY, cilt.39, sa.4, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 39 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.1177/1010428317698388
- Dergi Adı: TUMOR BIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Netrin-1, cancer, biomarker, therapeutic, target, dependence receptors, CELL-DEATH, DEPENDENCE RECEPTORS, SIGNAL-TRANSDUCTION, NEURONAL GUIDANCE, SURVIVAL FACTOR, DCC, ANGIOGENESIS, EXPRESSION, UNC5H, ACTS
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Kocaeli Üniversitesi Adresli: Evet
Özet
Netrin-1, a laminin-related protein, is known to be involved in the nervous system development. Recently, Netrin-1's involvement in other processes such as cell adhesion, motility, proliferation, and differentiation that are important for the development of epithelial tissues has been described. In addition, Netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated-5 homolog, have been linked to apoptosis and angiogenesis. Since these properties are essential for tumor development, Netrin-1 and its receptors have been reported to promote tumorigenesis in many types of cancers. Here, we review the Netrin-1 mediated regulation of cancer, its potential use as a biomarker, and the targeting of the Netrin-1 pathway to treat cancers.