Netrin-1 in cancer: Potential biomarker and therapeutic target?


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Kefeli U. , Ucuncu K. , Cabuk D. , Isik U., Sonkaya A., Acikgoz O., ...More

TUMOR BIOLOGY, vol.39, no.4, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 39 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.1177/1010428317698388
  • Title of Journal : TUMOR BIOLOGY
  • Keywords: Netrin-1, cancer, biomarker, therapeutic, target, dependence receptors, CELL-DEATH, DEPENDENCE RECEPTORS, SIGNAL-TRANSDUCTION, NEURONAL GUIDANCE, SURVIVAL FACTOR, DCC, ANGIOGENESIS, EXPRESSION, UNC5H, ACTS

Abstract

Netrin-1, a laminin-related protein, is known to be involved in the nervous system development. Recently, Netrin-1's involvement in other processes such as cell adhesion, motility, proliferation, and differentiation that are important for the development of epithelial tissues has been described. In addition, Netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated-5 homolog, have been linked to apoptosis and angiogenesis. Since these properties are essential for tumor development, Netrin-1 and its receptors have been reported to promote tumorigenesis in many types of cancers. Here, we review the Netrin-1 mediated regulation of cancer, its potential use as a biomarker, and the targeting of the Netrin-1 pathway to treat cancers.