Serum Growth Differentiation Factor 15 Levels in Newly Diagnosed Multiple Myeloma Patients

TARKUN P. , Atesoglu E. B. , MEHTAP Ö. , MUSUL M. M. , Hacihanefioglu A.

ACTA HAEMATOLOGICA, vol.131, no.3, pp.173-178, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.1159/000354835
  • Title of Journal : ACTA HAEMATOLOGICA
  • Page Numbers: pp.173-178


Background/Aims: Multiple myeloma (MM) is a hematological cancer associated with increased clonal malignant plasma cells. Growth differentiation factor 15 (GDF 15) is a protein that is highly expressed in the bone marrow mesenchynnal stem cells of patients with MM. This study investigated whether the clinical stage of the disease, treatment response and survival are affected by pretreatment serum GDF 15 levels. Methods: Serum GDF 15 levels were measured in 35 newly diagnosed MM patients and 27 healthy controls. The correlation between serum GDF 15 levels and various clinical and laboratory parameters was analyzed. Results:The study demonstrated significantly higher levels of GDF 15 in MM patients. There was a negative correlation between GDF 15 levels, hemoglobin and albumin levels, and a positive correlation between GDF 15 levels, CRP, creatinine, beta-2-microglobulin and stage. GDF 15 levels were lower in patients who could receive autologous stem cell transplantation compared to other groups, representing a statistically significant difference. However, in the survival analyses, GDF 15 level did not have an impact on survival. Conclusion: High serum levels of GDF 15 may indicate a poor treatment response. Our study supports the prognostic value of GDF 15 in MM. (C) 2013 S. Karger AG, Basel