Hydrophobicity or Hydrophilicity properties of boron carbide ceramic surface can be controlled by manipulating the roughness of the surface and thus the contact angle. In this study, the wettability of the boron carbide surface was manipulated by laser with different parameters. The contact angle was measured at 9(th) seconds after the droplet was dropped onto the laser-treated surface. Also, the change in contact angle in the first 9 seconds after the droplet was dropped was examined. For a more hydrophobic surface, it was aimed to have the largest contact angle at 9(th) seconds after the droplet was dropped and the smallest change with time in contact angle. The effects of laser scan speed, power, frequency and overlap rate on the contact angle of the treated surface were investigated using the Taguchi method. It was calculated to what extent each examined parameter affected the result. The effectiveness rates of the two most effective parameters which were scan speed and overlap rate were obtained. Since the results of the verification tests performed to confirm the results obtained are quite compatible with the results predicted by the Taguchi method, the Taguchi method can be regarded as a reliable method in optimizing laser parameters.