Examination of Mutations in the HBsAg and Polymerase Genes Induced by Pegylated Interferon Alpha and Oral Antivirals Used in the Treatment of Chronic Hepatitis B

Sargın E., AKHAN S., SAYAN M.

Viral Hepatit Dergisi, cilt.26, sa.3, ss.141-150, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/vhd.galenos.2020.2020.0017
  • Dergi Adı: Viral Hepatit Dergisi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.141-150
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objectives: The Hepatitis B Virus is a virus having high mutation frequency due to having a high replication capacity and not having error correction capability in reverse transcription. It is aimed to examine the mutations created by the oral antivirals used in CHB treatment on pol gene and S gene, to determine the clinical and epidemiological significance of these mutations, and to specify the development of drug resistance in long terms and the results it may cause. Secondly, it is aimed to determine whether the quantitative HBsAg titers are early markers for detecting drug resistance or not.