Aspirin, clopidogrel, and warfarin use and outcomes in a cohort of 580 patients discharged after hospitalization for decompensated heart failure

Kozdag G., Yaymaci M., Ertas G., Celikyurt U., ŞAHİN T., KILIÇ T., ...Daha Fazla

HEART AND VESSELS, cilt.27, sa.6, ss.568-575, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00380-011-0185-6
  • Dergi Adı: HEART AND VESSELS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.568-575
  • Anahtar Kelimeler: Aspirin, Clopidogrel, Warfarin, Chronic heart failure, Mortality, CONVERTING-ENZYME-INHIBITORS, CORONARY-ARTERY-DISEASE, SINUS RHYTHM, VENTRICULAR DYSFUNCTION, MYOCARDIAL-INFARCTION, ANTIPLATELET THERAPY, ADHESION MOLECULES, PLATELET-FUNCTION, RANDOMIZED-TRIAL, UNITED-STATES
  • Kocaeli Üniversitesi Adresli: Evet

Özet

The benefits of taking of aspirin, clopidogrel, and warfarin in relation to cardiovascular mortality and re-hospitalization in chronic heart failure (HF) patients have been called into question. We examined the outcomes (cardiac mortality and/or HF re-hospitalization) in patients discharged from our hospital between January 2003 and July 2009 after hospitalization for chronic decompensated HF. Of 580 HF patients (mean age, 63 +/- A 13 years; mean ejection fraction, 26 +/- A 9%, 63% with coronary disease and 37% without coronary disease), 207 patients (36%) died due to cardiovascular reasons, and 313 (54%) required HF re-hospitalization for decompensated HF during a 39 +/- A 14 month follow-up period. 101 (17%) patients were taking clopidogrel during enrollment in the study. When comparing patients who were on clopidogrel treatment with those who were not, clopidogrel was found to have a beneficial effect on cardiac mortality (27 vs. 38%, P = 0.04). In conclusion, in this observational prospective study, patients who used clopidogrel showed decreased cardiac mortality [HR, 0.566 (95% CI 0.332-0.964), P = 0.036] compared to patients who did not take clopidogrel. Clopidogrel had a beneficial effect on the survival of chronic HF patients in the long term.