NLRP1-Mediated Antidepressant Effect of Ketamine in Chronic Unpredictable Mild Stress Model in Rats


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Aricioglu F., Yalcinkaya C., Ozkartal C. S. , Tuzun E., Şirvancı S., Kucukali C. I. , ...Daha Fazla

PSYCHIATRY INVESTIGATION, cilt.17, ss.283-291, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 17
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30773/pi.2019.0189
  • Dergi Adı: PSYCHIATRY INVESTIGATION
  • Sayfa Sayıları: ss.283-291

Özet

Objective NOD-like receptor protein 1 (NLRP1) inflammasome complex has been recently associated with chronic unpredictable mild stress (CUMS) model of depression. Our aim was to investigate whether ketamine-induced antidepressant effect is associated with suppression of NLRP1.