NLRP1-Mediated Antidepressant Effect of Ketamine in Chronic Unpredictable Mild Stress Model in Rats

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Aricioglu F., Yalcinkaya C., Ozkartal C. S., Tuzun E., Şirvancı S., Kucukali C. I., ...Daha Fazla

PSYCHIATRY INVESTIGATION, cilt.17, ss.283-291, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30773/pi.2019.0189
  • Dergi Adı: PSYCHIATRY INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE
  • Sayfa Sayıları: ss.283-291
  • Anahtar Kelimeler: Depression, Ketamine, Inflammasome, NLRP1, Glia, NF-KAPPA-B, NITRIC-OXIDE SYNTHASE, NEURONAL NLRP1 INFLAMMASOME, MAJOR DEPRESSIVE DISORDER, ANIMAL-MODEL, EXPRESSION, NEUROINFLAMMATION, ACTIVATION, MECHANISMS, NEUROBIOLOGY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective NOD-like receptor protein 1 (NLRP1) inflammasome complex has been recently associated with chronic unpredictable mild stress (CUMS) model of depression. Our aim was to investigate whether ketamine-induced antidepressant effect is associated with suppression of NLRP1.