The Association of MYNN and TERC Gene Polymorphisms and Bladder Cancer in a Turkish Population

Polat F., Yılmaz M., Diler S. B.

UROLOGY JOURNAL, cilt.16, sa.1, ss.50-55, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.22037/uj.v0i0.4083
  • Dergi Adı: UROLOGY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.50-55
  • Anahtar Kelimeler: Bladder cancer, MYNN gene, polymorphism, TERC gen, COLORECTAL-CANCER, TELOMERE LENGTH, SUSCEPTIBILITY, LOCI, EXPRESSION
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Purpose: Researchers reported that, MYNN rs10936599 polymorphism is in strong or moderate linkage disequilibrium with SNPs within the 3q26.2 chromosomal regions that also include the TERC gene. In addition, it has been reported that MYNN rs10936599 had a strong cumulative association with bladder cancer risk, and TERC gene suppresses cell growth in bladder cancer cell lines. Therefore, we aimed to determine whether polymorphisms of MYNN rs10936599 and TERC rs2293607 play any roles for bladder cancer in the Turkish population in this study.