Positive impact of levetiracetam on emotional learning and memory in naive mice

CELIKYURT I. K., ULAK G., MUTLU O., AKAR F., MÜLAYİM S., ERDEN F., ...More

LIFE SCIENCES, vol.90, pp.185-189, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 90
  • Publication Date: 2012
  • Doi Number: 10.1016/j.lfs.2011.11.003
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.185-189
  • Keywords: Levetiracetam, Passive avoidance, Morris water maze, Mice, MORRIS WATER MAZE, ANTIEPILEPTIC DRUGS, INDUCED AMNESIA, SPATIAL MEMORY, AMYGDALA
  • Kocaeli University Affiliated: Yes

Abstract

Aims: The effect of an antiepileptic drug on cognitive function is of primary importance with respect to the patient's quality of life. Levetiracetam (LEV) is a novel antiepileptic drug used to treat epilepsy, but its effects on spatial and emotional learning and memory are not yet well understood. The goal of our study was to establish the effects of LEV (17 and 54 mg/kg, intraperitoneally (IP)) on spatial memory retrieval in the Morris water maze test and on acquisition and memory formation in the passive avoidance (PA) test in naive mice.