Positive impact of levetiracetam on emotional learning and memory in naive mice

CELIKYURT I. K., ULAK G., MUTLU O., AKAR F., MÜLAYİM S., ERDEN F., ...Daha Fazla

LIFE SCIENCES, cilt.90, ss.185-189, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.lfs.2011.11.003
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.185-189
  • Anahtar Kelimeler: Levetiracetam, Passive avoidance, Morris water maze, Mice, MORRIS WATER MAZE, ANTIEPILEPTIC DRUGS, INDUCED AMNESIA, SPATIAL MEMORY, AMYGDALA
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Aims: The effect of an antiepileptic drug on cognitive function is of primary importance with respect to the patient's quality of life. Levetiracetam (LEV) is a novel antiepileptic drug used to treat epilepsy, but its effects on spatial and emotional learning and memory are not yet well understood. The goal of our study was to establish the effects of LEV (17 and 54 mg/kg, intraperitoneally (IP)) on spatial memory retrieval in the Morris water maze test and on acquisition and memory formation in the passive avoidance (PA) test in naive mice.