Effects of caffeine on placental total nitrite concentration: A 21-day, vehicle-controlled study in rats

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Alasehirli B., Cekmen M., Nacak M., Balat A.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.66, no.2, pp.130-137, 2005 (Journal Indexed in SCI) identifier identifier


Background: Nitric oxide (NO) is a potent vasodilator that might have an important role in the modulation of maternal and fetal vascular tone during pregnancy. The effects of caffeine intake on maternal and fetal hemodynamic properties during pregnancy have been investigated in several human and animal studies. However, based on a literature search, there has been no study of placental total nitrite (a stable product of NO) concentration (PTNC) in pregnant humans or rats given caffeine.