Molecular Characterization of Drug Resistance in Hepatitis B Viruses Isolated from Patients with Chronical Infection in Turkey


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Asan A., SAYAN M. , AKHAN S. , Koruk S. T. , AYGEN B., SIRMATEL F., ...Daha Fazla

HEPATITIS MONTHLY, cilt.18, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 18 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5812/hepatmon.12472
  • Dergi Adı: HEPATITIS MONTHLY

Özet

Background: Hepatitis B virus (HBV) has a high mutation rate due to its unusual replication strategy leading to the production of a large number of virions with single and double mutations. The mutations, in turn, are associated with the development of drug resistance to nucleos(t)ide analogs (NUCs) in patients before and during NUCs therapy.