There are 35 proton-rich isotopes between Se-74 and Hg-196 that cannot be synthesized through neutron captures and beta(-)decays (s- and r-processes). A third process is therefore required for the production of these nuclei, the so-called p-process. The abundance and the origin of the p-nuclei are still not fully understood even though significant experimental and theoretical efforts in astrophysical modeling have been expended in the last two decades. The experimental studies with the activation method to measure cross sections of the relevant reactions have some limitations: the reaction product must be radioactive, should have an appropriate half-life, and its decay should be followed by proper gamma-radiations. If the cross section cannot be calculated with the radiation followed by the first beta decay of the product, it can be measured using the second beta decay as an alternative method. In this study, the method and candidate reactions for the cross-section measurements via the second beta decay of the reaction product using the activation method are discussed.