Determination of ALK Gene Rearrangment with FISH Method in Non Small Cell Lung Carcinoma


Seymen P. N. , Gumuslu E.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, cilt.9, ss.66-70, 2019 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 9 Konu: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/jarem.2019.2211
  • Dergi Adı: JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
  • Sayfa Sayısı: ss.66-70

Özet

Objective: Lung cancer is the carcinoma with the highest mortality and incidence. Genetic factors that cause lung cancer are the oncogenes and tumor suppressor genes underlying carcinogenesis. ALK gene is a transmembrane protein with tyrosine kinase activity. Because of inversion of ALK gene with EML4 gene, the EML4-ALK complex occurs. The EML4-ALK complex is continuously active, resulting in continuous cell proliferation. FISH is known as the "gold standard'' method to detect the EML4-ALK fusion gene, which is mostly seen in adenocarcinoma. In our study, we aimed to underlie the outcomes of detection of EML4-ALK gene rearrangement in clinics.