Determination of ALK Gene Rearrangment with FISH Method in Non Small Cell Lung Carcinoma


Seymen P. N. , Gumuslu E.

JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM, vol.9, pp.66-70, 2019 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.5152/jarem.2019.2211
  • Title of Journal : JOURNAL OF ACADEMIC RESEARCH IN MEDICINE-JAREM
  • Page Numbers: pp.66-70

Abstract

Objective: Lung cancer is the carcinoma with the highest mortality and incidence. Genetic factors that cause lung cancer are the oncogenes and tumor suppressor genes underlying carcinogenesis. ALK gene is a transmembrane protein with tyrosine kinase activity. Because of inversion of ALK gene with EML4 gene, the EML4-ALK complex occurs. The EML4-ALK complex is continuously active, resulting in continuous cell proliferation. FISH is known as the "gold standard'' method to detect the EML4-ALK fusion gene, which is mostly seen in adenocarcinoma. In our study, we aimed to underlie the outcomes of detection of EML4-ALK gene rearrangement in clinics.