Systemic lupus erythematosus complicated with Castleman disease: a case-based review

Demirkan F. G., Dogan S., Ucar A. K., SÖNMEZ H. E., AKTAY AYAZ N.

RHEUMATOLOGY INTERNATIONAL, cilt.41, sa.2, ss.475-479, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 41 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00296-020-04684-4
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.475-479
  • Anahtar Kelimeler: Systemic lupus erythematosus, Castleman disease, Lymphadenopathy, Pathology, LYMPH-NODE LESIONS, HYPERPLASIA, FEATURES, PATIENT
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Systemic lupus erythematosus (SLE) is a complex, chronic, multi-systemic autoimmune disease, characterized by miscellaneous clinical findings. Castleman disease (CD) is a rare lymphoproliferative disorder that may present with systemic symptoms. Herein, a SLE case complicated with CD is reported by comparing her clinical findings with previously reported patients. We reviewed the literature regarding cases of "Castleman disease" and "Systemic lupus erythematosus" by searching medical journal databases in MEDLINE, EMBASE, Scopus, and Web of Science. A case of a 16-year-old girl with SLE who had intraabdominal lymphadenopathy detected both by ultrasonography and abdominal magnetic resonance imaging is presented. The excision of the lymph node was performed by pediatric surgeons. Histopathological examination was compatible with CD. Hydroxychloroquine and steroid treatments were started after the operation. She achieved remission in 3 months. In the literature research, we found 10 articles describing 17 patients. To our best of knowledge, the presented case was the third pediatric case in the literature with SLE and coexistent CD. This case report and literature review suggests that CD should be considered while evaluating and following patients with autoimmune diseases.