Expression of KIR and C-type lectin receptors in Behcet's disease


Saruhan-Direskeneli G., Uyar F., Cefle A. , Onder S., Eksioglu-Demiralp E., Kamali S., et al.

RHEUMATOLOGY, cilt.43, ss.423-427, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 43 Konu: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1093/rheumatology/keh063
  • Dergi Adı: RHEUMATOLOGY
  • Sayfa Sayısı: ss.423-427

Özet

Objective. Behcet's disease (BD) is a multisystemic disorder with a possible underlying pathology of immune-mediated vasculitis. Genetic susceptibility associated with HLA-B*51 and B*2702 has been implicated in its pathogenesis. Considering the recently defined regulatory mechanisms of NK cells through HLA class I binding receptors, we hypothesized that interactions of NK and T cells through the NK receptors may be important in the pathogenesis of BD.