Comparison of Mesenchymal Stem Cells Isolated From Pulp and Periodontal Ligament

Hakki S. S., Kayis S. A., Hakki E. E., Bozkurt S. B., Duruksu G., Ünal Z. S., ...More

JOURNAL OF PERIODONTOLOGY, vol.86, pp.283-291, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 86
  • Publication Date: 2015
  • Doi Number: 10.1902/jop.2014.140257
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.283-291
  • Keywords: Cell biology, differentiation, gene expression, mesenchymal stem cell, molecular biology, regenerative medicine, HUMAN DENTAL-PULP, STROMAL CELLS, BONE REGENERATION, TISSUE, DIFFERENTIATION, CAPACITY, THERAPY, UTILITY, TEETH
  • Kocaeli University Affiliated: Yes

Abstract

Background: Cell-based therapy using mesenchymal stem cells (MSCs) seems promising to obtain regeneration of dental tissues. A comparison of tissue sources, including periodontal ligament (PDL) versus pulp (P), could provide critical information to select an appropriate MSC population for designing predictable regenerative therapies. The purpose of this study is to compare the proliferation and stemness and the MSC-specific and mineralized tissue-specific gene expression of P-MSCs and PDL-MSCs.