Efcient One‑Pot Synthesis of Indolhydroxy Derivatives Catalyzed by SnCl2, DFT Calculations and Docking Study
Chemistry Africa, cilt.5, sa.1, ss.827-839, 2022 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.1007/s42250-022-00374-9
- Dergi Adı: Chemistry Africa
- Sayfa Sayıları: ss.827-839
- Kocaeli Üniversitesi Adresli: Evet
Özet
In this work we used an efcient and simple synthesis for the preparation of new indolhydroxy derivatives that has been
performed by the reduction reaction of 2-nitrocinnamic acid or 2-nitrophenyl pyruvic acid with anhydrous stannous chloride (SnCl2) as a metal catalyst in diferent alcoholic solvents. During this transformation there was the involvement of
intramolecular elimination cyclization. In the case of the reduction of 2-nitrocinnamic acid we obtained hydroxyindole plus
hydroxyquinoline, on the other hand, the reduction of 2-nitrophenyl pyruvic acid gives hydroxyindole only, the products
were obtained in suitable yields. The structures of all the synthesized compounds were fully characterized by diferent
spectroscopic techniques such as 1
H NMR, 13C NMR. In addition, the obtained products have been tested in silico against
anti-human immunodefciency virus type 1 (HIV-1) and SARS-CoV-2 virus. The outcomes of this work are very promising
to develop more efcient antiviral compounds, indicating that these products may be a probable drugs for the SARS-CoV-2.