Protective effects of N-acetylcysteine on the peroxidative changes of rat lungs exposed to inhalation of thinners

Dillioglugil, MELTEM; Ilgazli, A; Maral, HALE; Sengul, C; Ozdemir, G; Ercin, C

doi:10.1111/j.1440-1843.2005.00758.x

Protective effects of N-acetylcysteine on the peroxidative changes of rat lungs exposed to inhalation of thinners

Atıf İçin Kopyala

Dillioglugil M. Ö. , Ilgazli A., Maral H. , Sengul C., Ozdemir G., Ercin C.

RESPIROLOGY, cilt.10, ss.615-619, 2005 (SCI İndekslerine Giren Dergi)

Cilt numarası: 10 Konu: 5
Basım Tarihi: 2005
Doi Numarası: 10.1111/j.1440-1843.2005.00758.x
Dergi Adı: RESPIROLOGY
Sayfa Sayıları: ss.615-619

Özet

Objective: Long-term inhalation of thinners may cause damage, both to the lungs and to other organ systems. It causes cellular damage via formation of reactive oxygen species. The lung is protected from oxidative stress by the glutathione (GSH) antioxidant system which can be augmented by the thiol drug, N-acetylcysteine (NAC). This study investigated the protective effect of NAC on peroxidative changes in rat lungs exposed to inhalation of thinners for 8 weeks.