Protective effects of N-acetylcysteine on the peroxidative changes of rat lungs exposed to inhalation of thinners

Dillioglugil M. Ö., Ilgazli A., Maral H., Sengul C., Ozdemir G., Ercin C.

RESPIROLOGY, vol.10, no.5, pp.615-619, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1440-1843.2005.00758.x
  • Journal Name: RESPIROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.615-619
  • Kocaeli University Affiliated: Yes

Abstract

Objective: Long-term inhalation of thinners may cause damage, both to the lungs and to other organ systems. It causes cellular damage via formation of reactive oxygen species. The lung is protected from oxidative stress by the glutathione (GSH) antioxidant system which can be augmented by the thiol drug, N-acetylcysteine (NAC). This study investigated the protective effect of NAC on peroxidative changes in rat lungs exposed to inhalation of thinners for 8 weeks.