TREATMENT OF ACUTE SPINAL-CORD INJURIES - COMPARISON OF THYROTROPIN-RELEASING-HORMONE AND NIMODIPINE


CEYLAN S. , ILBAY K. , BAYKAL S., CEYLAN S., SENER U., OZMENOGLU M., ...Daha Fazla

RESEARCH IN EXPERIMENTAL MEDICINE, cilt.192, ss.23-33, 1992 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 192 Konu: 1
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1007/bf02576254
  • Dergi Adı: RESEARCH IN EXPERIMENTAL MEDICINE
  • Sayfa Sayıları: ss.23-33

Özet

The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3 ml) i.v. 1 h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3 ml) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P < 0.01).