Fabrication and characterization as antibacterial effective wound dressing of hollow polylactic acid/polyurethane/silver nanoparticle nanofiber

Yilmaz S. S., AYTAÇ A.

JOURNAL OF POLYMER RESEARCH, cilt.29, sa.11, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s10965-022-03309-7
  • Dergi Adı: JOURNAL OF POLYMER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: Antibacterial, Wound dressing, Hollow, PLA, PU blend, Ag NPs, Electrospinning, SILVER NANOPARTICLES, COMPOSITE, FIBERS, CHITOSAN
  • Kocaeli Üniversitesi Adresli: Evet

Özet

In this study, hollow Polylactic Acid/Polyurethane/Silver Nanoparticle (PLA/PU/Ag NP) nanofibers were produced as the antibacterial effective wound dressing against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The produced wound dressings were reported to support the growth of mouse L929 fibroblast cells with cytotoxicity testing. In this way, these antibacterial effective wound dressings, which are predicted to can be used safely in the human body, were produced owning to design that will carry the features of the modern wound dressings. In addition to the development of nanomaterials with high elongation properties by using PLA and PU polymer blends, the fast-drying structures having too high a liquid absorption capacity were obtained owing to the hollow cross-sections of these nanomaterials. As a result of scanning electron microscope analysis (SEM), the surface images of hollow nanofibers were generally smooth, but as the amount of added Ag NP increased, the irregularities, beads, and Ag NP agglomerations along to nanofibers as regional were observed. Moreover, the hollow nanofibers were determined to have quite thin diameters. The surface, chemical, and thermal properties of nanofibers were examined with the Transmission Electron Microscope (TEM), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Thermal Gravimetric Analysis (TGA). Furthermore, it was proved by these analyses that the core of produced nanofibers was successfully removed.