Mitomycin-C prevents reformation of intra-abdominal adhesions after adhesiolysis

Cubukcu A., Alponat A., Gonullu N.

SURGERY, vol.131, no.1, pp.81-84, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1067/msy.2002.118316
  • Journal Name: SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.81-84
  • Kocaeli University Affiliated: No

Abstract

Background. Prevention of adhesions is central to surgical practice, because they cause significant morbidity. Inhibition of fibroblast proliferation is a way to prevent adhesions. Mitomycin-C (MMC) (Kyowa- Hakko-Kogyo Co, Ltd, Tokyo, Japan) is an alkylating agent that also inhibits fibroblast proliferation for up to a few weeks. We investigated the effect of MMC on the prevention of adhesion reformation.