Background. Prevention of adhesions is central to surgical practice, because they cause significant morbidity. Inhibition of fibroblast proliferation is a way to prevent adhesions. Mitomycin-C (MMC) (Kyowa- Hakko-Kogyo Co, Ltd, Tokyo, Japan) is an alkylating agent that also inhibits fibroblast proliferation for up to a few weeks. We investigated the effect of MMC on the prevention of adhesion reformation.