Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats


Komsuoglu-Celıkyurt I., Göçmez S. S., Mutlu O., Gacar N., Arıcıoğlu F., Utkan T.

LIFE SCIENCES, vol.89, pp.905-910, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89
  • Publication Date: 2011
  • Doi Number: 10.1016/j.lfs.2011.09.017
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.905-910
  • Keywords: 3-bromo-7-nitroindazole, ODQ, NO, Guanylate cyclase, Working memory, Reference memory, Emotional learning, Rats, LONG-TERM POTENTIATION, MEMORY FORMATION, IMPAIRS RETENTION, PROTEIN-KINASE, INHIBITION, CGMP, MICE, NITRATION, TASK, NEURODEGENERATION
  • Kocaeli University Affiliated: Yes

Abstract

Aims: The influence of 3-bromo-7-nitroindazole (3-Br 7-NI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor, and [1H-[1,2,4]-oxadiazole[4,3a]-quinoxaline-1-one] (ODQ), a highly selective, irreversible inhibitor of soluble guanylate cyclase (sGC), on working and reference memory and emotional learning was investigated in rats.