Akademik Veri Yönetim Sistemi
2nd International Congress of Multidisciplinary Medical and Health Sciences Studies, Ankara, Türkiye, 27 - 28 Mayıs 2024, ss.56
Alzheimer's disease is a neurodegenerative disease characterized by a decrease in daily vital activities and impaired cognitive abilities, accompanied by neuropsychiatric symptoms and behavioral changes. It is the most common type of dementia. Age is the most effective risk factor affecting the prevalence of Alzheimer's disease. The main pathological findings in this disease are the accumulation of abnormally amyloid beta (Aβ) plaques outside the cell and the formation of neurofibrillary tangles with the phosphorylation of tau proteins accumulated inside the cell. These pathologies lead to disconnection of neuron connections, neuronal death and ultimately brain atrophy. Alzheimer's disease can develop by being affected by many factors, both genetic and environmental. In studies on genetically inherited Alzheimer's, mutations were frequently found in genes encoding amyloid precursor protein (APP) and presenilin-1 (PSEN1). Alzheimer's disease, which occurs with advancing age, is one of the diseases that are frequently studied. Studies usually involve cellular approaches. This proposal we have prepared divides the concept of aging into two as the cellular level and the extracellular matrix (ECM) level. This designed study is about the investigation of the roles of brain extracellular matrix (ECM) age in Alzheimer's disease, independent of cellular aging. Our study is a 3D cell culture model created to understand how brain ECM age changes Alzheimer's pathogenesis.
This study, in which rejuvenation at ECM age causes changes in the pathogenesis of the disease, provides a model that can be used for new drug designs related to the matrix structure.